abstract：BACKGROUND:Reports on childhood cancer survivors estimated cumulative probability of developing secondary neoplasms vary from 3.3% to 25% at 25 years from diagnosis, and the risk of developing another cancer to several times greater than in the general population. METHODS:In our retrospective study, we have used the c...

journal_title：BMC cancer

authors： Jazbec J,Todorovski L,Jereb B

更新日期：2007-02-02 00:00:00

abstract：BACKGROUND:Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our pre...

journal_title：BMC cancer

authors： Chiappetta G,Ferraro A,Botti G,Monaco M,Pasquinelli R,Vuttariello E,Arnaldi L,Di Bonito M,D'Aiuto G,Pierantoni GM,Fusco A

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Brain metastases (BM) represent one of the most frequent complications related to cancer, and their treatment continues to evolve. We have evaluated the activity, toxicity and the impact on Quality of Life (QoL) of a concomitant treatment with whole brain radiotherapy (WBRT) and Temozolomide (TMZ) in patient...

journal_title：BMC cancer

authors： Addeo R,Caraglia M,Faiola V,Capasso E,Vincenzi B,Montella L,Guarrasi R,Caserta L,Del Prete S

更新日期：2007-01-25 00:00:00

abstract：BACKGROUND:Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significanc...

journal_title：BMC cancer

authors： Song Y,Song S,Zhang D,Zhang Y,Chen L,Qian L,Shi M,Zhao H,Jiang Z,Guo N

更新日期：2006-12-28 00:00:00

abstract：BACKGROUND:Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua),...

journal_title：BMC cancer

authors： Nyaga SG,Lohani A,Jaruga P,Trzeciak AR,Dizdaroglu M,Evans MK

更新日期：2006-12-27 00:00:00

abstract：BACKGROUND:Breast cancer in women is increasingly frequent, and care is complex, onerous and expensive, all of which lend urgency to improvements in care. Quality measurement is essential to monitor effectiveness and to guide improvements in healthcare. METHODS:Ten databases, including Medline, were searched electroni...

journal_title：BMC cancer

authors： Schachter HM,Mamaladze V,Lewin G,Graham ID,Brouwers M,Sampson M,Morrison A,Zhang L,O'Blenis P,Garritty C

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-A...

journal_title：BMC cancer

authors： Martin DN,Boersma BJ,Howe TM,Goodman JE,Mechanic LE,Chanock SJ,Ambs S

更新日期：2006-10-27 00:00:00

abstract：BACKGROUND:In a recent pilot report, we showed that Smac/DIABLO mRNA is expressed de novo in a subset of cervical cancer patients. We have now expanded this study and analyzed Smac/DIABLO expression in the primary lesions in 109 cervical cancer patients. METHODS:We used immunohistochemistry of formalin-fixed, paraffin...

journal_title：BMC cancer

authors： Arellano-Llamas A,Garcia FJ,Perez D,Cantu D,Espinosa M,De la Garza JG,Maldonado V,Melendez-Zajgla J

更新日期：2006-10-26 00:00:00

abstract：BACKGROUND:Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitione...

journal_title：BMC cancer

authors： Ryan AV,Wilson S,Wakelam MJ,Warmington SA,Dunn JA,Hobbs RF,Martin A,Ismail T

更新日期：2006-10-23 00:00:00

abstract：BACKGROUND:It remains unknown whether primary ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a homogeneous entity, as there are few reports of the results of cytogenetic or molecular analyses of these tumors. METHODS:We performed interphase fluorescence ...

journal_title：BMC cancer

authors： Tanimoto K,Sekiguchi N,Yokota Y,Kaneko A,Watanabe T,Maeshima AM,Matsuno Y,Harada M,Tobinai K,Kobayashi Y

更新日期：2006-10-20 00:00:00

abstract：BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...

journal_title：BMC cancer

authors： Letessier A,Sircoulomb F,Ginestier C,Cervera N,Monville F,Gelsi-Boyer V,Esterni B,Geneix J,Finetti P,Zemmour C,Viens P,Charafe-Jauffret E,Jacquemier J,Birnbaum D,Chaffanet M

更新日期：2006-10-13 00:00:00

abstract：BACKGROUND:Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to bladder cancer in particular when in combination with specific envi...

journal_title：BMC cancer

authors： McGrath M,Michaud D,De Vivo I

更新日期：2006-10-06 00:00:00

abstract：BACKGROUND:Oxidative damage to mitochondrial DNA has been implicated as a causative factor in a wide variety of degenerative diseases, aging and cancer. The modified guanine, 7,8-dihydro-8-oxoguanine (also known as 8-hydroxyguanine) is one of the major oxidized bases generated in DNA by reactive oxygen species and has ...

journal_title：BMC cancer

authors： Chatterjee A,Mambo E,Zhang Y,Deweese T,Sidransky D

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab with metronomic, low dose chemotherapy with cyclophosphamide (CTX) and methotrexate (MTX) in metastatic breast cancer (MBC). METHODS:Between April 2002 and June...

journal_title：BMC cancer

authors： Orlando L,Cardillo A,Ghisini R,Rocca A,Balduzzi A,Torrisi R,Peruzzotti G,Goldhirsch A,Pietri E,Colleoni M

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA...

journal_title：BMC cancer

authors： Powell AA,Akare S,Qi W,Herzer P,Jean-Louis S,Feldman RA,Martinez JD

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In this study, which examined the value of serum TRAP concentrations as ...

journal_title：BMC cancer

authors： Honig A,Rieger L,Kapp M,Krockenberger M,Eck M,Dietl J,Kämmerer U

更新日期：2006-07-25 00:00:00

abstract：BACKGROUND:Young age remains a controversial issue as a prognostic factor in breast cancer. Debate includes patients from different parts of the world. Almost 50% of patients with breast cancer seen at the American University of Beirut Medical Center (AUBMC) are below age 50. METHODS:We reviewed 1320 patients seen at ...

journal_title：BMC cancer

authors： El Saghir NS,Seoud M,Khalil MK,Charafeddine M,Salem ZK,Geara FB,Shamseddine AI

更新日期：2006-07-20 00:00:00

abstract：BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...

journal_title：BMC cancer

authors： Ferrandina G,Ranelletti FO,Martinelli E,Paglia A,Zannoni GF,Scambia G

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:The primary aim of treatment of a patient who has developed metastatic disease is palliation. The objectives of the current study are to describe and quantify the clinical management of women with metastatic breast cancer from the diagnosis of metastatic disease until death and to analyze differences between...

journal_title：BMC cancer

authors： Manders K,van de Poll-Franse LV,Creemers GJ,Vreugdenhil G,van der Sangen MJ,Nieuwenhuijzen GA,Roumen RM,Voogd AC

更新日期：2006-07-06 00:00:00

abstract：BACKGROUND:The effect of current therapies in improving the survival of lung cancer patients remains far from satisfactory. It is consequently desirable to find more appropriate therapeutic opportunities based on informed insights. A molecular pharmacological analysis was undertaken to design an improved chemotherapeut...

journal_title：BMC cancer

authors： Gemma A,Li C,Sugiyama Y,Matsuda K,Seike Y,Kosaihira S,Minegishi Y,Noro R,Nara M,Seike M,Yoshimura A,Shionoya A,Kawakami A,Ogawa N,Uesaka H,Kudoh S

更新日期：2006-06-30 00:00:00

abstract：BACKGROUND:Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible rol...

journal_title：BMC cancer

authors： Checinska A,Giaccone G,Hoogeland BS,Ferreira CG,Rodriguez JA,Kruyt FA

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:The association of nipple discharge with breast carcinoma has resulted in numerous women undergoing exploratory surgery to exclude malignancy. The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma. METHODS:All patients over a 14-y...

journal_title：BMC cancer

authors： Dillon MF,Mohd Nazri SR,Nasir S,McDermott EW,Evoy D,Crotty TB,O'Higgins N,Hill AD

更新日期：2006-06-23 00:00:00

abstract：BACKGROUND:Previous studies on bladder cancer have shown nodal involvement to be an independent indicator of prognosis and survival. This study aimed at developing an objective method for detection of nodal metastasis from molecular profiles of primary urothelial carcinoma tissues. METHODS:The study included primary b...

journal_title：BMC cancer

authors： Mitra AP,Almal AA,George B,Fry DW,Lenehan PF,Pagliarulo V,Cote RJ,Datar RH,Worzel WP

更新日期：2006-06-16 00:00:00

abstract：BACKGROUND:Human studies of dietary fat as a possible risk factor for cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC)--principally basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)--have produced inconsistent results. We had the opportunity to examine the association concurrently for a...

journal_title：BMC cancer

authors： Granger RH,Blizzard L,Fryer JL,Dwyer T

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Malignant pleural mesothelioma (MPM) is a tumor known to be resistant to conventional therapies. Thus, an in vivo model can represent an important tool for assessing the efficacy of novel approaches in the treatment of MPM.Presently, human MPM cells have been grown orthotopically in mice upon transplantation...

journal_title：BMC cancer

authors： Martarelli D,Catalano A,Procopio A,Orecchia S,Libener R,Santoni G

更新日期：2006-05-17 00:00:00

abstract：BACKGROUND:Therapeutic regulation of PPARdelta activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARdelta) activity in the context of intestinal tumourigenesis remain somewhat unclear. Contradictory evidence...

journal_title：BMC cancer

authors： Reed KR,Sansom OJ,Hayes AJ,Gescher AJ,Peters JM,Clarke AR

更新日期：2006-05-03 00:00:00

abstract：BACKGROUND:Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study its expression at protein level in HCC and its biological function for HCC cell growth. METHOD:Weste...

journal_title：BMC cancer

authors： Guo M,Li J,Wan D,Gu J

更新日期：2006-04-29 00:00:00

abstract：BACKGROUND:The incidence and survival of melanoma are increasing, but little is known about its long-term health effects in adult survivors. METHODS:A health survey was available from 996 melanoma survivors (577 treated with surgery alone, and 391 with combined treatments). Their medical/physiologic and psychosocial r...

journal_title：BMC cancer

authors： Stava C,Beck M,Weiss LT,Lopez A,Vassilopoulou-Sellin R

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenomatous polyposis coli (APC) gene has been reported to have a "gatekeeper" function in the colonic muc...

journal_title：BMC cancer

authors： Sarebø M,Skjelbred CF,Breistein R,Lothe IM,Hagen PC,Bock G,Hansteen IL,Kure EH

更新日期：2006-03-17 00:00:00

abstract：BACKGROUND:Chemotherapy for pancreatic carcinoma often has severe side effects that limit its efficacy. The glucocorticoid (GC) dexamethasone (DEX) is frequently used as co-treatment to prevent side effects of chemotherapy such as nausea, for palliative purposes and to treat allergic reactions. While the potent pro-apo...

journal_title：BMC cancer

authors： Zhang C,Kolb A,Büchler P,Cato AC,Mattern J,Rittgen W,Edler L,Debatin KM,Büchler MW,Friess H,Herr I

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate epigenetic status of cyclin A1 in human papillomavirus-associated cervical cancer. Y. Tokumaru et al., Cancer Res 64, 5982-7 (Sep 1, 2004)demonstrated in head and neck squamous-cell cancer an inverse correlation between cyclin A1 promoter hypermethylation and TP53 mutati...

journal_title：BMC cancer

authors： Kitkumthorn N,Yanatatsanajit P,Kiatpongsan S,Phokaew C,Triratanachat S,Trivijitsilp P,Termrungruanglert W,Tresukosol D,Niruthisard S,Mutirangura A

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results of concomitant application of radiochemotherapy for treating locally advanced head-and-neck carcino...

journal_title：BMC cancer

authors： Graf R,Hildebrandt B,Tilly W,Riess H,Felix R,Budach V,Wust P

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:The development of non-small cell lung carcinoma proceeds through a series of well-defined pathological steps before the appearance of invasive lung carcinoma. The molecular changes that correspond with pathology changes are not well defined and identification of the molecular events may provide clues on the...

journal_title：BMC cancer

authors： Tichelaar JW,Zhang Y,leRiche JC,Biddinger PW,Lam S,Anderson MW

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Modeling the relationship between age and mortality for breast cancer patients may have important prognostic and therapeutic implications. METHODS:Data from 9 registries of the Surveillance, Epidemiology, and End Results Program (SEER) of the United States were used. This study employed proportional hazards...

journal_title：BMC cancer

authors： Tai P,Cserni G,Van De Steene J,Vlastos G,Voordeckers M,Royce M,Lee SJ,Vinh-Hung V,Storme G

更新日期：2005-10-08 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells, and its expression has been correlated with increased tumour angiogenesis. Although numerous publications dealing with the measurement of circulating VEGF for diagnostic and therapeutic monitoring have been published, the re...

journal_title：BMC cancer

authors： Cressey R,Wattananupong O,Lertprasertsuke N,Vinitketkumnuen U

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:Presently available flow cytometric methods of bromodeoxyuridine (BrdUrd) labelling do not provide information on the cell cycle time (TC) and the growth fraction (GF). In this paper, we describe a novel and simple method to estimate TC and GF from flow cytometric analysis of a single tumour sample after Brd...

journal_title：BMC cancer

authors： Eidukevicius R,Characiejus D,Janavicius R,Kazlauskaite N,Pasukoniene V,Mauricas M,Den Otter W

更新日期：2005-09-22 00:00:00

abstract：BACKGROUND:The EphB4 receptor tyrosine kinase has been reported as increased in tumours originating from several different tissues and its expression in a prostate cancer xenograft model has been reported. METHODS:RT-PCR, western blotting and immunohistochemical techniques were used to examine EphB4 expression and pro...

journal_title：BMC cancer

authors： Lee YC,Perren JR,Douglas EL,Raynor MP,Bartley MA,Bardy PG,Stephenson SA

更新日期：2005-09-20 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer. METHODS:Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510...

journal_title：BMC cancer

authors： Cardillo MR,Gentile V,Ceccariello A,Giacomelli L,Messinetti S,Di Silverio F

更新日期：2005-09-05 00:00:00

abstract：BACKGROUND:Previous data from our laboratory has indicated that there is a functional link between the beta-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to determine if GIRK channels were expressed in lung cancers and ...

journal_title：BMC cancer

authors： Plummer HK 3rd,Dhar MS,Cekanova M,Schuller HM

更新日期：2005-08-18 00:00:00

abstract：BACKGROUND:Characterization of the linkage disequilibrium (LD) structure of candidate genes is the basis for an effective association study of complex diseases such as cancer. In this study, we report the LD and haplotype architecture and tagging-single nucleotide polymorphisms (tSNPs) for five DNA repair genes: ATM, M...

journal_title：BMC cancer

authors： Allen-Brady K,Camp NJ

更新日期：2005-08-09 00:00:00